E-4031
- Product Name
- E-4031
- CAS No.
- 113559-13-0
- Chemical Name
- E-4031
- Synonyms
- E-4031;E4031 diHCl;E-4031 (hydrochloride);1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb;Inhibitor,anti-arrhythmic,Potassium Channel,E4031,E 4031,KcsA,inhibit,E-4031,hERG;N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid;N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
- CBNumber
- CB8384065
- Molecular Formula
- C21H33Cl2N3O5S
- Formula Weight
- 510.47
- MOL File
- 113559-13-0.mol
E-4031 Property
- storage temp.
- -20°C
- solubility
- H2O: soluble
- form
- solid
- color
- off-white
- Stability:
- Hygroscopic
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M5060
- Product name
- E-4031
- Purity
- ≥98% (HPLC), lyophilized powder
- Packaging
- 0.1mg
- Price
- $264
- Updated
- 2024/03/01
- Product number
- M5060
- Product name
- E-4031
- Purity
- ≥98% (HPLC), lyophilized powder
- Packaging
- 0.5mg
- Price
- $458.4
- Updated
- 2024/03/01
- Product number
- 15203
- Product name
- E-4031 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 15203
- Product name
- E-4031 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- M5060
- Product name
- E-4031
- Purity
- ≥98% (HPLC), solid
- Packaging
- 1mg
- Price
- $1340
- Updated
- 2024/03/01
E-4031 Chemical Properties,Usage,Production
Uses
E-4031 has been used as:
- human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
- IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
- IKr blocker in rat ventricular myocytes
Biological Activity
Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.
Biochem/physiol Actions
E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.
storage
Room temperature (desiccate)
E-4031 Preparation Products And Raw materials
Raw materials
Preparation Products
E-4031 Suppliers
- Tel
- 4401179829988
- Fax
- 4402030 700 369
- customerservice@ascentscientific.co.uk
- Country
- United Kingdom
- ProdList
- 279
- Advantage
- 60
View Lastest Price from E-4031 manufacturers
- Product
- E-4031 113559-13-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-13